Browsing by Title
Now showing items 3587-3606 of 35682
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C. Iulius Caesar se gebruik van die konjunktief
(North-West University (South Africa), 1956)"No abstract" -
C.P. Hoogenhout se Geskiedenis van Josef, en Catharina, die dogter van die advokaat / Petrus Johannes Nienaber
(Johannesburg : Voortrekkerpers, 1940) -
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C2-substituted quinazolinone derivatives exhibit A1 and/or A2A adenosine receptor affinities in the low micromolar range
(Elsevier, 2020)Antagonists of the adenosine receptors (A1 and A2A subtypes) are widely researched as potential drug candidates for their role in Parkinson’s disease-related cognitive deficits (A1 subtype), motor dysfunction (A2A subtype) ... -
C3 amino-substituted chalcone derivative with selective adenosine rA1 receptor affinity in the micromolar range
(Springer, 2020)To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15–36 and 37–41) and structurally related ... -
C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase
(Thieme, 2017)Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ... -
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study
(Elsevier, 2018)Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ... -
Caffeine as a lead compound for the design of therapeutic agents for the treatment of Parkinson’s disease
(Bentham Science, 2015)The current pharmacological therapies for the treatment of Parkinson’s disease are mostly inadequate and recent, improved therapeutic agents are required. Two important molecular targets for the design of anti-parkinsonian ... -
Caffeine improves triathlon performance: a field study in males and females
(Human Kinetics, 2018)The ergogenic effect of caffeine on endurance exercise is commonly accepted. We aimed to elucidate realistically the effect of caffeine on triathlon event performance using a field study design, while allowing investigation ... -
The caking and swelling of South African large coal particles
(2015)The swelling and caking propensity of coals may cause operational problems such as channelling and excessive pressure build-up in combustion, gasification and specifically in fluidised-bed and fixed-bed operations. As a ... -
Calcium : magnesium ratio affects environmental stress sensitivity in the serpentine-endemic Alyssum inflatum (Brassicaceae)
(CSIRO Publishing, 2015)Plants endemic to serpentine soils are adapted to harsh environmental conditions typical of those soils, particularly, low (<1) calcium (Ca) : magnesium (Mg) ratios. We compared survival of two perennial Alyssum species ... -
Calcium is the switch in the moonlighting dual function of the ligand–activated receptor kinase phytosulfokine receptor 1
(BioMed Central, 2014)Background: A number of receptor kinases contain guanylate cyclase (GC) catalytic centres encapsulated in the cytosolic kinase domain. A prototypical example is the phytosulfokine receptor 1 (PSKR1) that is involved in ... -
Calculating operational value-at-risk (OpVaR) in a retail bank
(Faculty of Economic and Management Sciences, University of Pretoria, 2008)The management of operational value-at-risk (OpVaR) in financial institutions is presented y means of a novel, robust calculation technique and the influence of this value on the capital held by a bank for operational risk. ... -
Caledon and the Overberg: placid centre of a geographic microcosm?
(Afdeling Plaaslike en Streekgeskiedenisnavorsing van die lnstituut vir Geskiedenisnavorsing, RGN / Division for Local and Regional History Research, Institute for Historical Research, HSRC, 1988)• Opsomming: Die skerp styging in wolproduksie gedurende die 1850's het grootliks tot 'n kortstondige opbloeifase in die Overbergse dorp Caledon bygedra. In teenstelling met sommige ander Suid-Afrikaanse dorpe wat weens ... -
Calibration and validation of optical chlorophyll-measuring devices for use in predicting crude protein concentration in tropical grass herbage
(Wiley, 2016)The objective of this experiment was to evaluate the Fieldscout CM 1000 NDVI and Yara N-Tester as easy-to-use and cost-effective tools for predicting foliar chlorophylls (a, b and total) and crude protein (CP) concentrations ... -
A calibration neutron monitor for long-term cosmic ray modulation studies
(North-West University, 2006)The propagation of high-energy cosmic rays is influenced by the time-varying heliospheric magnetic field embedded in the solar wind, and by the geomagnetic field. To penetrate through this geomagnetic field, they must ... -
A calibration neutron monitor: energy response and instrumental temperature sensitivity
(American Geophysical Union, 2008)Neutron monitors are integral detectors of secondary cosmic rays. Since each of them has its own detection efficiency, energy spectra cannot readily be derived from their observations. To circumvent this problem, latitudinal ... -
A calibration neutron monitor: statistical accuracy and environmental sensitivity
(Elsevier, 2010)This paper is a follow-on of that of Krüger et al. [Krüger, H., Moraal, H., Bieber, J.W., Clem, J.M., Evenson, P.A., Pyle, K.R., Duldig, M.L., Humble, J.E. A calibration neutron monitor: energy response and instrumental ... -
Calibration of statistical methods used to constrain pulsar geometries via multiband light curve modelling
(SAIP, 2016)Since its launch in 2008, the Fermi Large Area Telescope (LAT) has detected over 200 γ-ray pulsars above 100 MeV. This population of pulsars is characterised by a rich diversity of light curve morphologies. Researchers ... -
A call for global action for rare diseases in Africa
(Springer Nature, 2020)The 11th International Conference on Rare Diseases and Orphan Drugs (ICORD), South Africa, included the Africa-Rare initiative launch and facilitated multi-stakeholder engagement in the challenges facing, and opportunities ...
