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Artificial membranes soaked with natural oils for in vitro drug premeability evaluations
(North-West University (South-Africa), 2019)Abstract not copied -
Combining selected medicinal plant extracts to improve wound healing of the skin
(North-West University (South-Africa), 2021)Throughout history plant-based medicines have been used for the treatment and management of wounds and some of these natural remedies are still very popular. Aloe vera gel is a well-known medicinal plant widely used in ... -
Comparison of drug permeability in rat, pig and human in vitro models
(2015)A crucial step in the drug discovery and development process is the assessment of membrane permeability properties of new chemical entities and researchers are constantly searching for cost-effective, high through-put ... -
Comparison of rat and porcine jejunum as in vitro models for P–glycoprotein mediated efflux using the Sweetana–Grass diffusion method
(North-West University, 2010)Absorption of drug substances across the intestinal epithelium is a complex and dynamic process. Counter transport proteins are responsible for the efflux of specific drug molecules after they have been absorbed. One of ... -
Curcumin delivery across excised sheep nasal mucosa from temperature sensitive gel formulations containing bioenhancers
(North-West University (South-Africa), 2021)Curcumin has been researched extensively for its medicinal properties such as the treatment of Alzheimer’s disease, depression, and other central nervous system (CNS) conditions. Curcumin, however, exhibits extremely poor ... -
Development of a double phase dosage form for enhanced peptide drug delivery
(2015)Parenteral administration remains the most utilised route of administration for therapeutic peptides due to low intestinal epithelial permeability. However, the most convenient and popular route of drug administration ... -
Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
(North-West University (South-Africa), 2020)Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These ... -
Development of a solid oral dosage form containing Artemisia afra extract
(North-West University (South-Africa), 2022)Artemisia afra is a medicinal plant traditionally used in the form of a tea infusion. The process of preparing an infusion is time-consuming with potential variation in phytochemical compounds as well as poor stability ... -
Development of curcumin containing direct compressible gastro-retentive tablets
(North-West University (South-Africa), 2021)Curcumin is the main active compound found in turmeric that exhibits many medicinal actions such as anti-inflammatory, anti-oxidative, antimicrobial and anti-cancer effects. However, the systemic delivery of curcumin by ... -
The effects of selected health supplements on drug intestinal epithelial permeation
(North-West University (South-Africa), 2019)With the growing popularity of health supplement usage to support and maintain a healthy body there is an increasing concern for possible drug-drug and drug-supplement interactions because health supplements are not subjected ... -
Effects of selected plant materials on in vitro wound healing using cell culture model
(North-West University (South-Africa), 2019)Since ancient times, wounds have been treated using plant based remedies. Of these remedies, Aloe species especially A. vera is probably the most prominent. Aloe vera is also the most studied of the Aloe genus in terms of ... -
Enhancement of nasal drug delivery by means of beneficial pharmacokinetic interactions
(North-West University (South-Africa), 2020)Drug products and dosage forms are seldom taken in complete isolation. The possibility exist to ingest drugs together with foods, herbs, dietary supplements and/or other drugs, which may result in pharmacokinetic or ... -
Evaluation of tricalcium citrate as a direct compressible diluent using the SeDeM Expert Diagram System
(North-West University (South-Africa), 2023)Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets ... -
An ex vivo investigation of the potential drug permeation enhancing effects of selected pepper extracts
(North-West University (South-Africa), 2019)Although the oral route is the most preferred and convenient route of drug administration when considering the patient, certain drugs (e.g. protein and peptide drugs) are mostly administrated by means of injections. This ... -
Extemporaneously prepared astaxanthin capsules for improved systemic delivery
(North-West University (South-Africa), 2020)Extemporaneous compounding of supplements or drugs has been practised since the beginning of pharmaceutical disease treatment approaches. In recent years extemporaneous compounding methods have been used for the formulation ... -
Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir
(2014)Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur ... -
Improvement of the pharmaceutical availability and membrane permeability of furosemide by formulation design
(North-West University (South-Africa), 2021)Furosemide is a well-known loop diuretic having weak acidic chemical properties. Furosemide belongs to the Biopharmaceutical Classification System (BCS) class IV because it has poor aqueous solubility and poor membrane ... -
In vitro evaluation of the toxicity profile of N-trimethyl chitosan chloride
(North-West University (South-Africa), 2000)The pharmaceutical scientist 1s confronted by numerous challenges in the area of developing new and effective delivery systems for new classes of drugs such as peptide and protein drugs. Due to the size and polarity ... -
In vitro release and stability of rooibos tea extract in topical formulations
(North-West University (South Africa), 2020)Aspalathus linearis (rooibos tea) is an indigenous plant that is commonly used to prepare a tea-based health beverage and aspalathin is the major flavonoid uniquely found in rooibos extract (RE). The use of RE in aqueous ... -
Investigating the absorptive and secretory transport of selected anti-malarial drugs
(North-West University, 2018)Malaria is one of the predominant infectious diseases affecting more than 200 million people a year worldwide. Artemisinin combination therapy (ACT) is currently the frontline treatment against the Plasmodium falciparum ...
