Browsing by Author "Gafane-Matemane, Lebo F."
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Associations of central and peripheral blood pressure with the renin-angiotensin-aldosterone system in healthy young adults: the African-PREDICT study
Gafane-Matemane, Lebo F.; Mokae, Nametsegang L.; Breet, Yolandi; Schutte, Aletta E.; Poglitsch, Marko (Springer Nature, 2020)This study investigated associations of brachial and central blood pressure (BP) with detailed renin-angiotensin-aldosterone system (RAAS) components in a healthy young population stratified according to ethnicity and sex. ... -
The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
Strauss-Kruger, Michél; Kruger, Ruan; Smith, Wayne; Gafane-Matemane, Lebo F.; Mokwatsi, Gontse; Schutte, Aletta E. (MDPI, 2020)The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ... -
Dietary sodium intake and its relationship to adiposity in young black and white adults: the African‐PREDICT study
Crouch, Simone H.; Ware, Lisa J.; Gafane-Matemane, Lebo F.; Kruger, Herculina S.; Van Zyl, Tertia; Van der Westhuizen, Bianca; Schutte, Aletta E. (Wiley, 2018)Obesity and salt intake are both established factors contributing to cardiovascular disease development. Recently, studies found a controversial positive relationship between dietary salt and obesity. Therefore, the ... -
Ethnicity and arterial stiffness
Schutte, Aletta E.; Kruger, Ruan; Gafane-Matemane, Lebo F.; Breet, Yolandi; Strauss-Kruger, Michél (AHA, 2020)Early vascular aging reflects increased arterial stiffness of central blood vessels at young chronological ages and powerfully predicts cardiovascular events and mortality, independent of routine brachial blood pressure ... -
Growth differentiating factor-15 and its association with traditional cardiovascular risk factors: the African-PREDICT study.
Vermeulen, Bridget; Schutte, Aletta E.; Gafane-Matemane, Lebo F.; Kruger, Ruan (Elsevier, 2020)Background and aims Growth differentiating factor-15 (GDF-15) is a stress-induced and cardio-protective cytokine, reported to be influenced by a number of cardiovascular risk factors. In older adults, GDF-15 associated ... -
Left ventricular diastolic function and its relationship with the renin-angiotensin-aldosterone system and amino-terminal prohormone B-type natriuretic peptide: the African-PREDICT study
Viana, B. (North-West University, 2018)Motivation: The association of left ventricular (LV) diastolic function markers with the renin-angiotensin-aldosterone system (RAAS) and amino-terminal prohormone B-type natriuretic peptide (Nt-proBNP) in older and diseased ... -
May Measurement Month 2017: an analysis of blood pressure screening results in South Africa-Sub-Saharan Africa
Woodiwiss, Angela J.; Kruger, Ruaan; Schutte, Aletta E.; Gafane-Matemane, Lebo F.; Ahiante, Blessing O.; Phalane, Edith; Crouch, Simone H. (Oxford Univ Press, 2019)Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. May Measurement Month (MMM) is a global initiative of the International Society of Hypertension (ISH) aimed at raising ... -
Relation of the renin-angiotensin-aldosterone system with potential cardiac injury and remodelling: the SABPA study
Gafane-Matemane, Lebo F.; Mokae, Nametsegang L.; Breet, Yolandi; Malan, Leoné (Taylor & Francis, 2020)Purpose: The renin-angiotensin-aldosterone system (RAAS) plays an important role in maintaining hemodynamic homeostasis. Ethnic disparities exist regarding RAAS activity due to sympathetic activity and sodium-water retention, ... -
The relationship of pulse pressure and pulse pressure amplification with the reninangiotensin- aldosterone system in young adults : the African-PREDICT study
Mokae, Nametsegang Lorato (North-West University (South-Africa). Potchefstroom Campus, 2019)Motivation: There are number of factors that are known to contribute to the elevation of blood pressure (BP) and the subsequent increase in cardiovascular risk. One of the most prominent systems is the renin-angiotensi ... -
The renin-angiotensin-aldosterone-system and left ventricular mass in young black and white adults: the African-PREDICT study
Du Toit, Wessel Lodewikus (North-West University (South-Africa), 2020)Motivation. The renin-angiotensin system (RAS) is a central regulatory component implicated in sodium and water homeostasis that affects blood volume and pressure. Dysregulation of this system results in increased blood ...