Browsing by Subject "Antiretroviral therapy"
Now showing items 1-10 of 12
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Antenatal care for HIV positive women
(North-West University, 2007)Approximately 29.1% of South African women of childbearing age tested HIV positive during their first antenatal visit in 2006 (DoH, 2007). This rate of HIV amongst the women of childbearing age reinforces the importance ... -
The association of HIV infection with plasma clot characteristics in black South Africans
(North-West University (South-Africa), 2021)INTRODUCTION AND AIM - Human immunodeficiency virus (HIV) infection is still one of the largest burdens to the world’s health, and South Africa reportedly has the highest prevalence in the world. HIV, as well as antiretroviral ... -
Association of predicted 10 years cardiovascular mortality risk with duration of HIV infection and antiretroviral therapy among HIV-infected individuals in Durban, South Africa
(BMC, 2019)Background: South Africa has the largest population of human immunodefciency virus (HIV) infected patients on antiretroviral therapy (ART) realising the benefts of increased life expectancy. However, this population may ... -
Blood levels of selective antiretroviral drugs over a period of time, in Sprague-Dawley rats
(North-West University, 2008)Selective antiretroviral (ARV) drugs are primarily metabolized by cytochrome P450 (CYP) enzymes, characteristically predisposed to variation, and are therefore primarily responsible for ARV pharmacokinetic variability and ... -
Fetal metabolic stress disrupts immune homeostasis and induces proinflammatory responses in human immunodeficiency virus type 1- and combination antiretroviral therapy-exposed infants
(Oxford Univ Press, 2017)Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological ... -
HIV treatment is associated with a twofold higher probability of raised triglycerides: pooled analyses in 21 023 individuals in sub-Saharan Africa
(Cambridge Univ Press, 2018)Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic ... -
The implementation of the Prevention of Mother-to-Child Transmission Guideline 2013 by the Western Cape Department of Health : an evaluation
(North-West University (South Africa), 2019)The World Health Organisation introduced Option B+ in 2012 to eliminate HIV (vertical transmission from mother to child). The Western Cape Government, Department of Health followed by releasing its Prevention of Mother to ... -
The influence of HIV infection on vascular function in an African population
(North-West University, 2010)The prevention and treatment of non-communicable diseases, such as cardiovascular disease, is marginalized in South Africa by the overwhelming prevalence of human immunodeficiency virus (HIV). HIV infection and/or the ... -
Metabolic risks at birth of neonates exposed in utero to HIV-antiretroviral therapy relative to unexposed neonates: an NMR metabolomics study of cord blood
(Springer, 2016)Introduction Antiretroviral therapy (ART) for HIV-infected pregnant women is highly effective in preventing mother-to-child transmission (PMTCT) of the virus, but deleterious metabolic and mitochondrial observations in ... -
Retrospective clinical analysis of adverse drug reactions associated with antiretroviral therapy in Tlokwe district, South Africa
(Taylor & Francis, 2018)Background: South Africa has the highest number of patients on antiretroviral therapy (ART) globally. Various obstacles were identified that influence effective reporting of adverse drug reactions (ADRs) in resource-limited ...
