Browsing by Subject "Benzoate"
Now showing items 1-7 of 7
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AKSM2A en AKSM2B ensiemtoets optimalisering en rekombinante uitdrukking
(North-West University (South Africa). Potchefstroom Campus, 2019)Glisienkonjugasie is ʼn Fase 2-biotransformasieweg wat verantwoordelik is vir die detoksifisering van xenobiotika soos bensoaat en salisilaat. Hierdie biotransformasieweg is gekonserveerd en speel ʼn baie belangrike rol in ... -
Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B
(Springer, 2018)Benzoate (found in milk and widely used as preservative), salicylate (present in fruits and the active component of aspirin), dietary polyphenols produced by gut microbiota, metabolites from organic acidemias, and medium-chain ... -
Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway
(Elsevier, 2015)Thorough investigation of the glycine conjugation pathway has been neglected. No defect of the glycine conjugation pathway has been reported and this could reflect the essential role of glycine conjugation in hepatic ... -
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
(Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
The identification of genetic variation in the acyl-CoA synthetase genes (ACSM2A and ACSM2B)
(North-West University (South Africa), Potchefstroom Campus, 2016)Investigations into the role of the glycine conjugation pathway and specifically the functioning and significant importance of the mitochondrial medium-chain ligases have seriously been neglected over the last 30 years. ... -
A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids
(Taylor & Francis, 2014)A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the ... -
Xenobiotic/medium chain fatty acid: CoA ligase - a critical review on its role in fatty acid metabolism and the detoxification of benzoic acid and aspirin
(Taylor & Francis, 2016)Introduction: Activation of fatty acids by the acyl-CoA synthetases (ACSs) is the vital first step in fatty acid metabolism. The enzymatic and physiological characterization of the human xenobiotic/medium chain fatty acid: ...
