Browsing by Subject "Benzocycloalkanone"

Now showing items 1-2 of 2

Anti-trypanosomal and antimalarial properties of tetralone derivatives and structurally related benzocycloalkanones

Beteck, Richard M.; Legoabe, Lesetja J.; Isaacs, Michelle; Khanye, Setshaba D.; Laming, Dustin (MDPI, 2019)

Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan diseases that share overlapping endemic areas in sub-Saharan Africa. The causative agent for malaria has developed resistance ...
Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors

Qhobosheane, Malikotsi A.; Legoabe, Lesetja J.; Petzer, Jacobus P.; Beteck, Richard M.; Josselin, Béatrice (Elsevier, 2020)

Protein kinases are important drug targets, especially in the area of oncology. This paper reports the synthesis and biological evaluation of new 7-azaindole derivatives bearing benzocycloalkanone motifs as potential protein ...