Browsing by Subject "Benzonitrile"

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Monoamine oxidase inhibition by C4-substituted phthalonitriles

Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)

It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ...
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B

Van der Walt, Mietha M.; Terre'Blanche, Gisella; Lourens, Anna C.U.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)

It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on ...
Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors

Van der Walt, Mietha Magdalena (North-West University, 2013)

Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease (PD). However, the long-term use of L-DOPA is associated with the development of motor fluctuations and dyskinesias. Treatment mainly ...