Browsing by Subject "Biotransformation"
Now showing items 1-10 of 11
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Adverse effect of heavy metals (As, Pb, Hg, and Cr) on health and their bioremediation strategies: a review
(Springer, 2018)Currently, heavy metal pollution becomes a severe problem whole over the world, and these toxic metals enter into the environment either by natural phenomena or due to extensive industrialization. The discharged effluents ... -
An analytical method to investigate the estrogen metabolism in women taking combined oral contraceptives
(North-West University, 2018)The human body is exposed to numerous (endogenous and exogenous) toxins daily. The body has a protective mechanism to help detoxify certain toxins, through biotransformation processes. However, when exposure exceeds the ... -
Association analysis of genetic variants related to biotransformation, estrogen metabolism, and oxidative stress
(North-West University (South Africa), 2023)In a previous study by the NWU eBOSS research group, urinary oestrogen biotransformation metabolite levels and blood oxidative stress markers were measured in African and Caucasian premenopausal South African women. ... -
Development and validation of LC-ESI-MS/MS methods for quantification of 27 free and conjugated estrogen-related metabolites
(Elsevier, 2020)An imbalance in the estrogen metabolism has been associated with an increased risk of breast cancer development. Evaluation of the estrogen biotransformation capacity requires monitoring of various estrogen metabolites. ... -
Effect of oral contraception on biotransformation, oxidative stress and oxidative damage
(North-West University (South Africa), Potchefstroom Campus, 2015)The first hormonal oral contraceptive was released in 1960, giving women a more efficient way of controlling pregnancy and family planning. A combined oral contraceptive (COC) consists of an estrogen and a progestin compound. ... -
The effect of sulforaphane on oxidative stress and biotransformation in HepaRG cells
(North-West University, 2013)Sulforaphane is an isothiocyanate found in high concentrations in cruciferous vegetables like broccoli. Sulforaphane has received much attention due to the evidence that it inhibits phase I carcinogen-bioactivating enzymes ... -
Establishing three-dimensional cell culture models to measure biotransformation and toxicity
(North-West University, Potchefstroom Campus, 2018)A great proportion of new chemical entities will be terminated from the clinical drug development pipeline as a result of deficiencies in drug absorption, distribution, biotransformation and elimination as well as potential ... -
Investigation of the bi-substrate kinetics of a recombinant human glycine N-acyltransferase with a known non-synonymous single nucleotide polymorphism (N156S)
(North-West University (South Africa), Potchefstroom Campus, 2015)Biotransformation is fast becoming a buzzword of our time. This is due to the ever increasing exposure of humans to xenobiotic substances. The detoxification of these xenobiotics occur via various detoxifying mechanisms ... -
Phase 2 biotransformation : the targeted profiling of glycine amino acid conjugation
(North-West University (South Africa), Potchefstroom Campus, 2015)The hepatic biotransformation system plays an important role in drug metabolism and toxicity and has been studied quite extensively. The importance of the very first biotransformation reaction discovered, namely phase 2 ... -
Phase I and II biotransformation in patients with chronic fatigue
(North-West University (South Africa), 2020)This thesis, titled: ‘Phase I and II biotransformation in patients with chronic fatigue’, forms part of the research and development programme of the Centre for Human Metabolomics at the NWU. There is no consensus definition ...
