Browsing by Subject "Black South African population"

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Associations between specific ApoE genetic variants and their interactions with environmental factors in relation to the lipid profile of black South Africans

Meades, Lize (2014)

Introduction: Cardiovascular disease (CVD) is the leading cause of global mortality and its prevalence is increasing among black South Africans in spite of their favourable lipid profile. Apolipoprotein E (ApoE) is a ...
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study

Chikowore, Tinashe; Cockeran, Marike; Conradie, Karin R.; Van Zyl, Tertia (Elsevier, 2018)

Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ...
The influence of genetic polymorphisms of fibrinogen genes on changes in total fibrinogen and fibrinogen gamma prime concentrations over time in black South Africans

Jobse, Ané (2014)

INTRODUCTION AND AIM - Cardiovascular disease is globally a major risk factor for morbidity and mortality. It is caused by various factors, one of which is an abnormal haemostatic process. Fibrinogen is a haemostatic factor ...