Browsing by Subject "DOTS"

Now showing items 1-3 of 3

The altered urine metabolome induced by DOTS therapy in pulmonary tuberculosis patients

Opperman, Monique (North-West University (South Africa), 2023)

Metabolomics holds great promise for studying complex diseases like tuberculosis (TB), where treatment outcomes are influenced by a combination of biological, environmental, and social factors. This study aimed to gain a ...
Experiences of patients having tuberculosis (TB) regarding the use of Directly Observed Treatment Short-Course (DOTS) in the North West Province, South Africa

Serapelwane, Maserapelo G.; Davhana-Maselesele, Mashudu; Masilo, Gaboipolelwe M. (AOSIS, 2016)

Background: Tuberculosis (TB) management remains a major challenge despite the implementation of Directly Observed Treatment Short-Course (DOTS). Some of the challenges include defaulting treatment, low TB cure rates and ...
Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: a pharmacometabolomics study

Combrink, Monique; Du Preez, Ilse; Loots, Du Toit; Ronacher, Katharina; Walzl, Gerhard (Mary Ann Liebert, 2019)

Pharmacometabolomics is a rapidly emerging omics science signaling the convergence of clinical pharmacology, metabolomics, precision medicine, and biomarker research. Tuberculosis (TB) treatment outcomes have complex ...