Browsing by Subject "Depression"
Now showing items 1-10 of 82
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Animal models of major depressive disorder and the implications for drug discovery and development
(Taylor & Francis, 2019)Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is ... -
Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances
(Elsevier, 2023)Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins and ... -
Antidepressant efficacy of high and low frequency transcranial magnetic stimulation in the FSL/FRL genetic rat model of depression
(Elsevier, 2016)Repetitive Magnetic Stimulation (rTMS) has appeared to be a potential non-invasive antidepressant method, which implies non-convulsive focal stimulation of the brain through a time varying magnetic field. The antidepressant ... -
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ... -
Behavioral, neuroendocrine and neurochemical studies on agomelatine in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)1. Introduction. There is currently a large body of evidence suggesting that stressful early life experiences, such as maternal separation and social isolation, may play a role in the development of major depressive disorder ... -
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Cardiovascular function and psychological distress in urbanised black South Africans : the SABPA study
(North-West University, 2009)Motivation: Cardiovascular disease (CVD) is one of the leading causes of death worldwide, with the greatest mortality rates occurring in low and middle income countries. The increase in the prevalence of risk factors such ... -
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point: the SABPA study
(Elsevier, 2017)Background Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ... -
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
(Elsevier, 2016)Background Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear. Objectives ... -
Core self-evaluations as a moderator for the effects of role overload and powerlessness on ill-health
(North-West University, 2007)Employees in the Occupational Risk Division (ORD) of a large petrochemical company experience many difficult situations on a regular basis. This division of the company comprises the emergency services, the security and ...
