Browsing by Subject "Dose variation"

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The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time

Terre'Blanche, Gisella; Heyer, Nicolette; Bergh, Jacobus J.; Mienie, Lodewyk J.; Harvey, Brian Herbert; Van der Schyf, Cornelius J. (Springer, 2011)

Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ...