Browsing by Subject "Indole‐5,6‐dicarbonitrile"

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Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives

Chirkova, Zhanna V.; Petzer, Anél; Petzer, Jacobus P.; Kabanova, Mariya V.; Filimonov, Sergey I. (Elsevier, 2015)

Recent studies have found that phthalonitrile derivatives are remarkably potent inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to further determine the structure-activity relationships (SARs) for MAO ...
Optimization of pyrrolo[3,4‐f]indole‐5,7‐dione and indole‐5,6‐dicarbonitrile derivatives as inhibitors of monoamine oxidase

Chirkova, Zhanna V.; Petzer, Anél; Hitge, Rialette; Petzer, Jacobus P.; Kabanova, Mariya V. (Wiley, 2019)

In recent studies, we have investigated the monoamine oxidase (MAO) inhibition properties of pyrrolo[3,4‐f]indole‐5,7‐dione and indole‐5,6‐dicarbonitrile derivatives. Since numerous high potency MAO inhibitors are present ...