Browsing by Subject "N-acylglutamates"

Now showing items 1-1 of 1

Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters

Dercksen, M.; Mienie, L.J.; Van der Westhuizen, F.H.; Ijlst, L.; Duran, M. (Elsevier, 2014)

Hyperammonemia is a frequent finding in various organic acidemias. One possible mechanism involves the inhibition of the enzyme N-acetylglutamate synthase (NAGS), by short-chain acyl-CoAs which accumulate due to defective ...