Browsing by Subject "N-trimethyl chitosan chloride"
Now showing items 1-6 of 6
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Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
(North-West University (South-Africa), 2020)Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These ... -
Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles
(2014)Malaria is an infectious disease caused by various forms of the Plasmodium parasite. It is responsible for thousands of deaths yearly with 90 % of those deaths being in sub-Saharan Africa, thus making it a disease of global ... -
Hemocompatibility of N–trimethyl chitosan chloride nanoparticles
(2014)Research on nanoparticles for pharmaceutical applications has become increasingly popular in recent years. N-trimethyl chitosan chloride (TMC) is a cationic polymer that can enhance absorption across mucosal surfaces. It ... -
In vitro evaluation of the toxicity profile of N-trimethyl chitosan chloride
(North-West University (South-Africa), 2000)The pharmaceutical scientist 1s confronted by numerous challenges in the area of developing new and effective delivery systems for new classes of drugs such as peptide and protein drugs. Due to the size and polarity ... -
Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride
(Taylor & Francis, 2010)The aim of this study was to evaluate the ability of TMC, with different degrees of quaternization, to increase insulin absorption in vivo following nasal and rectal administration in rats. Two batches of TMC with different ... -
Permeation of excised intestinal tissue by insulin released from Eudragit® L100/Trimethyl chitosan chloride microspheres
(North-West University, 2013)The purpose of this research project was to develop and characterise matrix type microspheres prepared from Eudragit® L100, containing insulin as model peptide drug as well as an absorption enhancer, N-trimethyl chitosan ...
