Browsing by Subject "Neurodevelopmental model"

Now showing items 1-3 of 3

N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges

Swanepoel, Twanette; Möller, Marisa; Harvey, Brian Herbert (Springer, 2018)

Rationale Schizophrenia is associated with prenatal inflammation and/or postnatal stressors such as drug abuse, resulting in immune-redox dysfunction. Antioxidants may offer therapeutic benefits. Objectives The objective ...
Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: role of corticosterone, oxytocin, and vasopressin

Harvey, Brian H.; Regenass, Wilmie; Dreyer, Walter; Möller, Marisa (Sage, 2019)

Background: The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared ...
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex

Regenass, Wilmie; Möller, Marisa; Harvey, Brian Herbert (Sage, 2018)

Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...