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    • Hereditary tyrosinemia type 1 metabolites impair DNA excision repair pathways 

      Van Dyk, E.; Steenkamp, A.; Koekemoer, G.; Pretorius, P.J. (Elsevier, 2010)
      Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate ...