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dc.contributor.authorGlyn, M.C.
dc.contributor.authorVan Rooyen, J.M.
dc.contributor.authorSchutte, R.
dc.contributor.authorHuisman, H.W.
dc.contributor.authorFourie, C.M.T.
dc.contributor.authorSmith, W.
dc.contributor.authorMalan, L.
dc.contributor.authorMalan, N.T.
dc.contributor.authorMels, C.M.C.
dc.contributor.authorSchutte, A.E.
dc.identifier.citationGlyn, M.C. et al. 2012. Ethnicity-specific differences in L-arginine status in South African men. Journal of human hypertension, 26(12):737-743. []en_US
dc.description.abstractThe aetiology for an increasing incidence of hypertensive cardiovascular disease amongst Africans in southern Africa is unclear. Hypertension may be induced by inadequate release of L-arginine-derived nitric oxide impairing vascular tone regulation. In addition, asymmetric dimethylarginine (ADMA) is associated with cardiovascular disease. We compared profiles of L-arginine in African and Caucasian men of similar age with cardiovascular risk factors. We studied 163 Caucasian and 132 African men, respectively, (20 to 70 years) measuring serum L-arginine, ADMA, creatinine, urea, symmetric dimethylarginine (SDMA) and blood pressure. L-arginine levels were significantly lower, whereas blood pressure and pulse wave velocity were significantly higher in African men. Simple linear regression showed ADMA more strongly associated with L-arginine in Caucasians (r=0.59 vs 0.19), whereas association of SDMA with L-arginine was significant only in Caucasians (r=0.43 vs 0.001). The stronger association of L-arginine with ADMA in Caucasian men was confirmed by multiple regression analysis (β=0.46 vs 0.25). Our findings show that the relationship of cardiovascular risk factors with serum L-arginine and some of its catabolites is different in African and Caucasian men and that this may be associated with a relatively higher prevalence of hypertension in African men.en_US
dc.publisherNature Publishing Groupen_US
dc.subjectblood pressureen_US
dc.subjectarterial complianceen_US
dc.titleEthnicity-specific differences in L-arginine status in South African menen_US
dc.contributor.researchID22419853 - Glyn, Matthew Colin Patrick
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID22945717 - Smith, Wayne
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID12076341 - Mels, Catharina Martha Cornelia
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor

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