Browsing Faculty of Health Sciences by Title
Now showing items 1-20 of 2404
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1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B
(Elsevier, 2019)The present study investigates the monoamine oxidase (MAO) inhibition properties of a series of ten 5-aryl-1,3,4-oxadiazol-2-ylbenzenesulfonamides. The target compounds were synthesized by dehydration of the corresponding ... -
1,3,7-Triethyl-substituted xanthines-possess nanomolar affinity for the adenosine A1 receptor
(Elsevier, 2015)Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive deficits. Antagonism of the adenosine A1 receptor may offer therapeutic benefits in complex neurological diseases, such as ... -
1-Bromo-2-(10 β-dihydroartemisinoxy)-ethane
(IUCr, 2010)The title compound, C17H27BrO5, DEB, is a derivative of artemisinin which is used in malaria therapy. The OR-group at C12 is cis to the CH3-group at C11 and axially oriented on ring D which has a chair conformation. The ... -
A 10-year follow-up study of demographic and cardiometabolic factors in HIV-infected South Africans
(Clinics Cardive Publishing, 2019)Objectives: Understanding of the interplay between human immunodeficiency virus (HIV) and cardiovascular disease, especially in Africa, is limited to evidence from longitudinal studies. Therefore the demographic profile ... -
11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons
(RSC, 2018)11-Azaartemisinin (11-Aza) is a potent anti-malarial drug more readily able to form cocrystals than its parent compound. 13 new 1 : 1 and 2 : 1 cocrystal phases from 25 mono- and bi-functional acids are reported here in ... -
2-Acetylphenol analogs as potent reversible monoamine oxidase inhibitors
(Dove Press, 2015)Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds ... -
2-Aminopyrimidines as dual adenosine A1/A2A antagonists
(Elsevier, 2015)In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this ... -
2-Benzylidene-1-indanone analogues as dual adenosine A1/A2a receptor antagonists for the potential treatment of neurological conditions
(Thieme, 2019)Previous studies explored 2-benzylidine-1-tetralone derivatives as innovative adenosine A1 and A2A receptor antagonists for alternative non-dopaminergic treatment of Parkinson’s disease. This study’s aim is to investigate ... -
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives ... -
A 2-Decade Appraisal of African Nursing Scholarship: 1986-2006
(Wiley-Blackwell, 2009)This paper is a description of a study about articles published about nursing in Africa from 1986 to 2006. METHODS: An exhaustive database search of articles written by nurses or articles related to nursing in Africa was ... -
2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related ... -
2020 International Society of Hypertension global hypertension practice guidelines
(AHA, 2020)Context and Purpose of This Guideline Statement of Remit To align with its mission to reduce the global burden of raised blood pressure (BP), the International Society of Hypertension (ISH) has developed worldwide ... -
2020 International Society of Hypertension global hypertension practice guidelines - lifestyle modification. Reply
(Wolters Kluwer, 2020)The 2020 ISH Global Hypertension Practice Guidelines [1] include a detailed list of lifestyle modifications with varying levels of evidence for the reduction of blood pressure and cardiovascular risk. We listed some novel ... -
24-Hour central blood pressure: reference values for healthy individuals. The international 24hour ambulatory aortic blood pressure consortium (I24ABC)
(Wolters Kluwer, 2019)Objective: Central systolic blood pressure (cSBP) differs from peripheral SBP (pSBP) and may have higher prognostic relevance, but the normal values in ambulatory conditions are unknown. We present reference values for ... -
25 Years of research on global asphyxia in the immature rat brain
(Elsevier, 2017)Hypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates. Preterm infants have additional complications, as prematurity by itself increases the risk of encephalopathy. Currently, therapy for this ... -
3-Coumaranone derivatives as inhibitors of monoamine oxidase
(Dove Press, 2015)The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ... -
3D analysis of synaptic vesicle density and distribution after acute foot‐shock stress by using serial section transmission electron microscopy
(Wiley, 2017)Behavioural stress has shown to strongly affect neurotransmission within the neocortex. In this study, we analysed the effect of an acute stress model on density and distribution of neurotransmitter‐containing vesicles ... -
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
(Taylor & Francis, 2019)A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted ... -
5-Substituted 2-benzylidene-1-tetralone analogues as A1 and/or A2A antagonists for the potential treatment of neurological conditions
(Elsevier, 2017)Adenosine A1 and A2A receptors are attracting great interest as drug targets for their role in cognitive and motor deficits, respectively. Antagonism of both these adenosine receptors may offer therapeutic benefits in ... -
6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity
(Wiley, 2020)In this study, we synthesized novel nitro quinolone‐based compounds and tested them in vitro against a panel of Gram‐positive and Gram‐negative pathogens including Mycobacterium tuberculosis (MTB), Pseudomonas aeruginosa ...
