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dc.contributor.authorMoutloatse, Gontse P.
dc.contributor.authorLindeque, Zander
dc.contributor.authorVan Reenen, Mari
dc.contributor.authorReinecke, Carolus J.
dc.contributor.authorSchoeman, Johannes C.
dc.identifier.citationMoutloatse, G.P. et al. 2017. Metabolic risks of neonates at birth following in utero exposure to HIV-ART: the amino acid profile of cord blood. Metabolomics, 13(8): Article no 89. []en_US
dc.identifier.issn1573-3890 (Online)
dc.description.abstractIntroduction Untargeted metabolomics of cord blood indicated that antiretroviral therapy to HIV-infected mothers (HIV-ART) did not compromise the exposed neonates with regard to the stress of neonatal hypoglycaemia at birth. However, identified biomarkers reflected stress in their energy metabolism, raising concern over developmental risks in some newborns exposed to ART. Objectives This study addresses the concern over HIV-ART-induced metabolic perturbations by expanding the metabolomics study to the amino acid profiles in cord blood collected at birth from newborns either exposed or unexposed to HIV-ART in utero. Methods Amino acid profiles derived from liquid chromatographic triple quadruple spectra of cord blood from neonates exposed and unexposed to HIV-ART (cohort 1) were investigated using a metabolomics approach. Amino acid data, generated by ultra performance liquid chromatography–tandem mass spectrometry from similar cases (cohort 2), were included for comparison. Results Multivariate and supporting statistics indicated differentiation between the exposed and unexposed neonates in both cohorts, caused by a general decrease or downregulation of amino acid concentrations in the cord blood samples from the exposed cases. Specifically, significant upregulation of aspartic acid in both cohorts and downregulation of arginine, and of threonine, tryptophan and lysine in cohorts 1 and 2, respectively, were observed. Conclusions The benefits of ART for HIV-infected pregnant women are well established. However, the amino acid profile of cord blood, obtained from the two independent cohorts, adds to observed metabolic risks of in utero HIV-ART-exposed newborns. These risks could potentially have adverse consequences for the future health of some exposed infantsen_US
dc.subjectHIV-antiretroviral therapyen_US
dc.subjectCord blood metabolomeen_US
dc.subjectAmino acid profileen_US
dc.subjectAspartic aciden_US
dc.subjectMetabolic risken_US
dc.titleMetabolic risks of neonates at birth following in utero exposure to HIV-ART: the amino acid profile of cord blooden_US
dc.contributor.researchID12662275 - Lindeque, Jeremie Zander
dc.contributor.researchID10055037 - Reinecke, Carolus Johannes
dc.contributor.researchID12791733 - Van Reenen, Mari
dc.contributor.researchID20212100 - Moutloatse, Gontse Panache
dc.contributor.researchID20382863 - Schoeman, Johannes Cornelius

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