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Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue

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dc.contributor.authorKriel, Frederik H.
dc.contributor.authorBester, Cornelius J.
dc.contributor.authorZeevaart, Jan Rijn
dc.contributor.authorSzucs, Zoltan
dc.contributor.authorVan Staden, Johan A.
dc.contributor.researchID10070095 - Bester, Cornelius Johannes Jacobus
dc.contributor.researchID16951484 - Zeevaart, Jan Rijn
dc.date.accessioned2016-08-19T07:26:20Z
dc.date.available2016-08-19T07:26:20Z
dc.date.issued2015
dc.description.abstractDinuclearbisphosphinogold(I) dithiocarbamato, BPDTC, was previously found to have antitumour activity in vitro. 198Au radiolabelled BPDTC (radiochemical yield of 70 ± 6 % and radiochemical purity of[95 %) was used to determine its in vivo biodistribution in Sprague-Dawley rats. Gamma scintigraphs were performed over a period of 48 h and final radioactivity measurements of harvested organs of the test animals after termination was performed at 2, 4 and 48 h. The study successfully showed the biodistribution of the gold complex, with the highest uptake of the compound being observed in the lungs, liver and spleenen_US
dc.description.sponsorshipNuclear Technologies in Medicine and the Biosciences Initiative (NTeMBI), a national technology platform developed and managed by the South African Nuclear Energy Corporation (Necsa) and funded by the Department of Science and Technology. Biomed (Mintek)en_US
dc.identifier.citationKriel, F.H. et al. 2015. Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue. Journal of radioanalytical and nuclear chemistry, 303(3):1949-1954. [https://doi.org/10.1007/s10967-014-3816-4]en_US
dc.identifier.issn0236-5732
dc.identifier.issn1588-2780 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/18326
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs10967-014-3816-4
dc.identifier.urihttps://doi.org/10.1007/s10967-014-3816-4
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectRadiolabellingen_US
dc.subject198Auen_US
dc.subjectGold(I)en_US
dc.subjectBisphosphineen_US
dc.subjectDithiocarbamateen_US
dc.subjectBiodistributionen_US
dc.titleBiodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogueen_US
dc.typeArticleen_US

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