Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue
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Abstract
Dinuclearbisphosphinogold(I) dithiocarbamato,
BPDTC, was previously found to have antitumour activity
in vitro. 198Au radiolabelled BPDTC (radiochemical yield
of 70 ± 6 % and radiochemical purity of[95 %) was used
to determine its in vivo biodistribution in Sprague-Dawley
rats. Gamma scintigraphs were performed over a period of
48 h and final radioactivity measurements of harvested
organs of the test animals after termination was performed
at 2, 4 and 48 h. The study successfully showed the biodistribution
of the gold complex, with the highest uptake of
the compound being observed in the lungs, liver and
spleen
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Kriel, F.H. et al. 2015. Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue. Journal of radioanalytical and nuclear chemistry, 303(3):1949-1954. [https://doi.org/10.1007/s10967-014-3816-4]